![]() ![]() Sanger sequencing method is considered as “first generation” technology and it is useful and effective in sequencing DNA fragments of 500-900 base pairs. Then Frederik Sanger developed the termination chain sequencing method, published in 1977, which became popular and has been used by research centers around the world until today. The first DNA sequencing method was developed by Maxam-Gilbert, however, it was only capable of sequencing a few nucleotides at a time. This file contains symbols that represent the sequence of nitrogenous bases – A, C, G, T – present in the sample. ![]() ![]() DNA sequencing is based on equipment that reads a DNA sample and generates an electronic file. The study of changes in gene function through structural changes or changes in surrounding proteins without changes in the DNA sequence is known as epigenetics.DNA sequencing is the exact determination of the order in which nucleotides are found. The DNA expression is controlled by changes in the DNA sequence itself, but it can also be regulated by changes in the helix structure or changes in surrounding proteins without changing the DNA sequence. In order for the genetic information stored in DNA to actually play a role, it should be expressed as a transcript (RNA). By assessing the open state of closed chromatin condensed into histone proteins for gene expression, the accessible region of RNA polymerase can be inferred, or the transcription factor binding site and nucleosome (nucleosome) location information can be acquired. Macrogen provides a high level of genetic sequencing data quickly based on its NGS (next generation sequencing) performance, which ranks first in Korea and fifth in the world, and supports personalized sample tests. This DNA processing technique uses sodium bisulfite, a substance that converts unmethylated cytosine to uracil, to observe the level of methylation of DNA by analyzing the nucleotide sequence afterward.ĪTAC is a technique used to analyze accessible DNA regions through NGS (Next Generation Sequencing). ![]() WGBS (Whole Genome Bisulfite Sequencing) is a key NGS technique that can check methylation. Offering a total genomic solution to researchers all over the world based on our extensive experiences and know-how accumulated over the years, Macrogen leads the field of precision medicine by utilizing NGS technology We provide genome analysis services suitable for research, such as whole genome, exome, transcriptome, epigenome, metagenome, and single cell multi-omics sequencing and bioinformatics results based on the data. Macrogen produces a large amount of genome information every year using various kinds of equipment, provides quicker and more accurate genome analysis service at an economical price to assist in studies conducted by researchers, and offers a diagnostic service to the public. This is expected to speed up the realization of precision medicine that can provide treatments optimized for individual patients based on their genome. Recently, mostly in the medical field, clinical studies based on NGS are actively conducted and many studies are in progress to identify genetic variance and the functions of new genes. Especially since the cost and time for genome analysis gradually decreased, the demand for genome analysis for living organisms including humans has rapidly increased and became available to use in various research. There has been rapid progress in technologies related to NGS since its commercialization in 2000, which has produced a large volume of genome information for use in research. Macrogen is a global leader in precision medicine that is capable of predicting and diagnosing diseases through NGS information-based R&D and collaboration with medical institutions, presenting personalized treatment plans according to genetic characteristics. ![]()
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